Lucas Masoero spent his youth years in FC Independiente Rivadavia’s academy and in 2015 he moved up playing for the first team. Two campaigns later, he made a move to the Argentinian CD Maipu.

In the summer of 2018 Masoero joined PFC Lokomotiv Plovdiv to win the Bulgarian Cup (2018/19). In the next season Loko with him in the squad triumphed with the Cup for a second year in a row and also added the Bulgarian Supercup trophy to the club museum.